We present a case of a 63-year-old man with a past medical history of end stage kidney disease on dialysis that was admitted to the hospital due to a native valve infective endocarditis secondary to a healthcare associated bloodstream infection caused by an uncommon gram-negative bacillus: Enterobacter cloacae. The patient was treated with antimicrobial therapy for 6 weeks and was later discharged. In this case, we will discuss the risk factors, pathophysiology diagnostic criteria and treatment options associated with this rare infection.