Cardiovascular disease (CVD) is a significant burden on aged people, caregivers, and health-care systems. Vascular structural and functional changes occur over time, increasing the risk of cardiovascular disease (CVD). The world's ageing population underscores the need to better understand how ageing increases CVD so that new solutions can be developed to combat the problem. This study illustrates some key unresolved clinical issues that we experience in daily cardiovascular practise when caring for older patients. The authors then go over the present state of knowledge on the mechanisms involved in cardiovascular ageing, as well as the possibility of targeting novel pathways linked to endothelial dysfunction, mitochondrial oxidative stress, chromatin remodelling, and genomic instability. Finally, the authors discuss important features of vascular healing, such as autologous bone marrowderived stem cell transplantation in older individuals. Risk factors for cardiovascular disease (CVD) are dominated by age 1, 2. Indeed, modern treatments for acute coronary syndromes and stroke have aided in the extension of life expectancy. Although a huge accomplishment on an individual level, the resulting demographic change poses one of the world's most significant challenges to social and health care systems. The number of people aged 65 and up will treble from 12% in 2010 to 22% in 2040. Indeed, by 2020, the number of persons aged 60 and up will surpass that of children under the age of five. The rate of population ageing is rapidly growing over the world, especially in low- and middle-income countries (e.g., Chile, China, Iran, and Russia).