Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age and is characterized by irregular menstrual cycles, hyperandrogenism and polycystic ovaries. This case investigation details the long-term treatment strategies employed for a 32-year-old woman diagnosed with PCOS. The patient presented with persistent symptoms including menstrual irregularities, hirsutism and weight gain despite initial management efforts. A comprehensive, individualized treatment plan was developed incorporating lifestyle modifications, pharmacotherapy and hormonal treatments. Key interventions included a tailored diet and exercise program, metformin for insulin resistance and combination oral contraceptives for menstrual regulation and symptom control. Over a 24-month period, significant improvements were observed in menstrual regularity, reduction in hirsutism and overall quality of life. This case underscores the importance of a multifaceted approach in the long-term management of PCOS and highlights the positive outcomes achievable through personalized treatment strategies.