Since the COVID-19 episode, numerous conventional Chinese medications play played imperative parts in battling COVID-19. Unfortunately, exploring on removing center Chinese drugs through clinical information mining is as yet inadequate. In the current exploration, we gathered 862 TCM remedies from 320 moderate COVID-19 patients. All solutions were mined through the affiliation rule mining, and afterward the Gancao-Banxia center pair was screened. We developed thusly a Gancan-Banxia against moderate COVID‐19 related quality set comprising of 49 focuses by breaking down the dynamic elements of Gancan-Banxia. Utilitarian enhancement examination cleared that Gancao-Banxia could manage provocative reaction pathways, viral protection and invulnerable reactions. Center proteins PPI network uncovered eight center targets.